Enabling the Next Era of Alpha Radioligand Therapies

Meridian is creating the first industrial-scale Pb-212 supply chain—unlocking the full potential of alpha radioligand therapies and driving a new wave of innovation in radiopharmaceuticals.

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Our Mission
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The Future of Targeted Alpha Therapy

The next breakthrough in precision oncology begins with Pb-212—a powerful alpha-emitting isotope with the potential to revolutionize cancer treatment.

At Meridian Radiopharmaceuticals, we are committed to solving the Pb-212 supply challenge, ensuring biotech and pharmaceutical companies have access to the high-purity isotopes they need to bring life-saving therapies to market.

“Pb-212 represents a transformative step forward in cancer care. By ensuring a reliable, scalable supply, we are unlocking the full potential of alpha-targeted radiopharmaceuticals.

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Robert Mendelsohn
Chief Scientific Officer
Our Technology

Scalable. Efficient. Reliable.

Meridian has developed a proprietary, patent-pending manufacturing platform that allows for high-yield production of Pb-212 at a scale previously thought unattainable.

✔ Laboratory-scale validation underway – Expected completion Q2 2025
✔ Key partnership agreements in progress –
Enabling commercial-scale deployment within Q2 2025
✔ Non-carrier-added, high-purity Pb-212 –
Designed for pharmaceutical-grade applications

We are actively working with industry stakeholders and regulatory bodies to ensure our production aligns seamlessly with commercial needs.

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Why Pb-212?
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A Next-Generation Alpha-Emitter for Targeted Radiopharmaceuticals

While beta-emitting therapies like Lu-177 have made strides in cancer care, alpha-emitters like Pb-212 offer a new level of precision and potency.

✔ High-energy alpha decay for potent tumor cell destruction
✔ Short half-life (~10.6 hours) enables controlled dosing with reduced radiation exposure
✔ Efficient integration into targeted radiopharmaceuticals using established chelation chemistry


Despite its enormous potential, Pb-212 has remained in short supply—hindering its widespread adoption. We are solving this problem.

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