Enabling the Next Era of Alpha Radioligand Therapies

Meridian is creating the first industrial-scale alpha-emitting radionuclide supply chain—unlocking the full potential of alpha radioligand therapies and driving a new wave of innovation in radiopharmaceuticals.

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Our Mission
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The Future of Targeted Alpha Therapy

The next breakthrough in precision oncology begins with a powerful alpha-emitting isotope with the potential to revolutionize cancer treatment.

At Meridian Radiopharmaceuticals, we are committed to solving the alpha supply challenge, ensuring biotech and pharmaceutical companies have access to the high-purity isotopes they need to bring life-saving therapies to market.

“Alpha-emitters represents a transformative step forward in cancer care. By ensuring a reliable, scalable supply, we are unlocking the full potential of alpha-targeted radiopharmaceuticals.

Robert Mendelsohn
Chief Scientific Officer
Our Technology

Scalable. Efficient. Reliable.

Meridian has developed a proprietary, patent-pending manufacturing platform that allows for high-yield production of alpha-emitters at a scale previously thought unattainable.

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    Laboratory-scale validation underwayExpected completion Q3 2025
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    Key partnership agreements in progress – Enabling commercial-scale deployment within Q3 2025
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    Non-carrier-added, high-purity– Designed for pharmaceutical-grade applications

We are actively working with industry stakeholders and regulatory bodies to ensure our production aligns seamlessly with commercial needs.

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Why Pb-212?
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A Next-Generation Alpha-Emitter for Targeted Radiopharmaceuticals

While beta-emitting therapies like Lu-177 have made strides in cancer care, alpha-emitters offer a new level of precision and potency.

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    Alpha decays emit helium nuclei, allowing for a greater chance of double-strand breaks in cancer cells.
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    A high linear energy transfer (LET) allows for delivery of concentrated energy directly to targeted cancer cells
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    Efficient integration into targeted radiopharmaceuticals using established chelation chemistry

Despite their enormous potential, alpha-emitters have remained in short supply—hindering its widespread adoption. We are solving this problem.

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